Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Author:

Evers Raymond1,Piquette-Miller Micheline2,Polli Joseph W.3,Russel Frans G.M.4,Sprowl Jason A.5,Tohyama Kimio6,Ware Joseph A.7,de Wildt Saskia N.8,Xie Wen9,Brouwer Kim L.R.10,

Affiliation:

1. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co.; Kenilworth New Jersey USA

2. Leslie Dan Faculty of Pharmacy; University of Toronto; Toronto Ontario Canada

3. Mechanistic Safety and Drug Disposition, GlaxoSmithKline; King of Prussia Pennsylvania USA

4. Department of Pharmacology and Toxicology; Radboud University Medical Center; Nijmegen The Netherlands

5. Department of Pharmaceutical; Social and Administrative Sciences, School of Pharmacy, D'Youville College School; Buffalo New York USA

6. Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company; Fujisawa Kanagawa Japan

7. Department of Small Molecule Pharmaceutical Sciences; Genentech; South San Francisco California USA

8. Department of Pharmacology and Toxicology and Department of Intensive Care; Radboud University Medical Center, Nijmegen, The Netherlands, and Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital; Rotterdam The Netherlands

9. Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy; University of Pittsburgh; Pittsburgh Pennsylvania USA

10. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy; University of North Carolina; Chapel Hill North Carolina USA

Funder

National Institute of General Medical Sciences

National Institutes of Health

National Institute of Environmental Health Sciences

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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