Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

Author:

Matter Matthias S.12,Marquardt Jens U.13,Andersen Jesper B.14,Quintavalle Cristina2,Korokhov Nikolay1,Stauffer Jim K.5,Kaji Kosuke1,Decaens Thomas1,Quagliata Luca2,Elloumi Fathi6,Hoang Tanya2,Molinolo Alfredo7,Conner Elizabeth A.1,Weber Achim8,Heikenwalder Mathias910,Factor Valentina M.1,Thorgeirsson Snorri S.1

Affiliation:

1. Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda MD

2. Institute of Pathology, University Hospital of Basel; Basel Switzerland

3. Department of Medicine I; Johannes Gutenberg University; Mainz Germany

4. Biotech Research and Innovation Centre, University of Copenhagen; Copenhagen Denmark

5. Cancer and Inflammation Program, National Cancer Institute-Frederick; Frederick MD

6. National Cancer Institute, CCR at Leidos Inc., National Institutes of Health; Bethesda MD

7. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health; Bethesda MD

8. Institute of Surgical Pathology, University Hospital Zurich; Zurich Switzerland

9. Institute of Virology, Technische Universität München/Helmholtz Zentrum München; Munich Germany

10. Division of Chronic Inflammation and Cancer; German Cancer Research Center; Heidelberg Germany

Funder

National Institutes of Health/National Cancer Institute/Center for Cancer Research

Schweizerische Stiftung für Medizinisch-Biologische Stipendien

University of Basel/Lichtenstein Stiftung

Oncosuisse

Publisher

Wiley

Subject

Hepatology

Reference30 articles.

1. Genetic landscape and biomarkers of hepatocellular carcinoma;Zucman-Rossi;Gastroenterology,2015

2. Immunity, inflammation, and cancer;Grivennikov;Cell,2010

3. Hepatocellular carcinoma;El-Serag;N Engl J Med,2011

4. Cancer immunology-analysis of host and tumor factors for personalized medicine;Ogino;Nat Rev Clin Oncol,2011

5. Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease;Preisegger;Lab Invest,1999

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