A tool for selective inline quantification of co-eluting proteins in chromatography using spectral analysis and partial least squares regression

Author:

Brestrich Nina1,Briskot Till1,Osberghaus Anna1,Hubbuch Jürgen1

Affiliation:

1. Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT); Engler-Bunte-Ring 1 76131 Karlsruhe Germany

Funder

MWK, Baden-W�rttemberg, GErmany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference31 articles.

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3. An optical biosensor for real-time chromatography monitoring: Breakthrough determination;Bracewell;Biosens Bioelectron,1998

4. Host cell protein quantification by Fourier transform mid infrared spectroscopy (FT-MIR);Capito;Biotechnol Bioeng,2013

5. Monitoring the fractionation of a whey protein isolate during dead-end membrane filtration using fluorescence and chemometric methods;Elshereef;Biotechnol Prog,2010

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