The role of exo‐miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Author:

Kzar Al‐Shukri Hamzah H.1,Abdul‐Jabbar Ali Sana2,Al‐Akkam Karam Akram2,Hjazi Ahmed3ORCID,Rasulova Irodakhon45,Mustafa Yasser Fakri6ORCID,Al‐Saidi Dahlia N.7,Alasheqi Mohammed Qasim8,Alawadi Ahmed91011,Alsaalamy Ali12

Affiliation:

1. Department of Biochemistry, College of Veterinary Medicine Al‐Qasim Green University Babylon Iraq

2. Pharmacy Department Al Safwa University College Karbalaa Iraq

3. Department of Medical Laboratory Sciences, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Al‐Kharj Saudi Arabia

4. School of Humanities, Natural & Social Sciences New Uzbekistan University Uzbekistan

5. Department of Public Health Samarkand State Medical University Samarkand Uzbekistan

6. Department of Pharmaceutical Chemistry, College of Pharmacy University of Mosul Mosul Iraq

7. Department of Medical Laboratories Technology AL‐Nisour University College Baghdad Iraq

8. College of Nursing National University of Science and Technology Dhi Qar Iraq

9. College of Technical Engineering The Islamic University Najaf Iraq

10. College of Technical Engineering The Islamic University of Al Diwaniyah Al Diwaniyah Iraq

11. College of Technical Engineering The Islamic University of Babylon Babylon Iraq

12. College of Technical Engineering Imam Ja'afar Al‐Sadiq University Kirkuk Iraq

Abstract

AbstractSmall extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the wide range of biomolecules that make up the cargo of exosomes. Exosomes are crucial for intercellular communication because they let cells share information and signaling chemicals. They are involved in various physiological and pathological processes, including immune responses, tissue regeneration, cancer progression, and neurodegenerative diseases. In conclusion, it is essential to continue research into exosome‐based cancer medicines to advance understanding, improve treatment plans, create personalized tactics, ensure safety, and speed up clinical translation.

Publisher

Wiley

Subject

Cell Biology,General Medicine

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