Affiliation:
1. Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences Department of Endocrinology, Peking Union Medical College Hospital Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China
2. Department of Medical Research Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China
3. Department of Endocrinology, Beijing Chao-yang Hospital Capital Medical University Beijing China
Abstract
AbstractScope: Circadian rhythms profoundly impact metabolism and the gut microbiota. A maternal high‐fat diet (HFD) exerts effects on the metabolic syndrome of adult offspring in a sex‐specific manner, the underlying mechanisms, however, remain unclear.Methods and results: Female mice are fed an HFD and raise their offspring on a standard chow diet until 24 weeks. The glucose tolerance, insulin sensitivity, and diurnal rhythms of serum metabolic profiles are assessed in male and female adult offspring. Simultaneously, 16S rRNA is applied to characterize gut microbiota diurnal rhythms. The study finds that maternal HFD tends to deteriorate glucose tolerance and impairs insulin sensitivity in male offspring, but not female offspring, which can be associated with the circadian alterations of serum metabolic profiles in male offspring. As expected, maternal HFD sex‐specifically alters diurnal rhythms of the gut microbiota, which exhibits putative associations with metabolic profiles in males.Conclusions: The present study identifies the critical role of gut microbiota diurnal rhythms in triggering sex‐biased metabolic diurnal rhythms in response to maternal HFD, at least in part. As early life may be a critical window for preventing metabolic diseases, these findings provide the basis for developing chronobiology applications targeting the gut microbiota to combat early metabolic alterations, especially in males.
Funder
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Beijing Municipal Science and Technology Commission
Subject
Food Science,Biotechnology