Affiliation:
1. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology 13 Hangkong Road Wuhan Hubei 430030 China
2. Department of Obstetrics and Gynecology, The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology 26 Shengli Street Wuhan Hubei 430014 P. R. China
Abstract
ScopeMagnesium plays an important role in regulating glucose metabolism. The study attempts to explore association between magnesium status and single nucleotide polymorphisms (SNPs) of gene involved in magnesium absorption‐transient receptor potential membrane melastatin 6 (TRPM6) and gestational diabetes mellitus (GDM) riskMethods and resultsA nested case–control study including 170 GDM cases and matched 340 controls is conducted based on Tongji Birth Cohort. Dietary, serum, and urine magnesium are evaluated before the diagnosis of GDM. Compared to the lowest tertile, women in the highest tertile of serum magnesium are at a lower risk of GDM (adjusted odds ratio [aOR] 0.42, 95% confidence intervals [CI] 0.21–0.84). Serum magnesium is inversely associated with insulin and homeostatic model assessment of insulin resistance (β = −0.05, p = 0.002; β = −0.04, p = 0.001, respectively). The aOR for GDM in carriers of the CT or CC genotypes of TRPM6 rs2274924 compared with carriers of the TT genotype is 2.76 (95% CI 1.78–4.26). Dietary magnesium is positively associated with serum magnesium (β = 0.02, p = 0.004), but not with GDM risk.ConclusionSerum magnesium and the TRPM6 rs2274924 polymorphism are associated with the risk of GDM.
Funder
National Natural Science Foundation of China
Subject
Food Science,Biotechnology