Relatively favorable prognosis for MLL -rearranged childhood acute leukemia with reciprocal translocations

Author:

Yang Liu12ORCID,Ding Lixia23,Liang Jianwei2,Chen Jing1,Tang YanJing1,Xue Huiliang1,Gu Longjun1,Shen Shuhong12,Li Benshang14,Chen Jing12

Affiliation:

1. Department of Hematology and Oncology; Shanghai Children's Medical Center; Shanghai Jiao Tong University School of Medicine; Shanghai China

2. Key Laboratory of Pediatric Hematology and Oncology Ministry of Health; Department of Hematology and Oncology; Shanghai Children's Medical Center; Shanghai Jiao Tong University School of Medicine; Shanghai China

3. Pediatric Translational Medicine Institute; Shanghai Jiao Tong University School of Medicine; Shanghai China

4. Shanghai Ministry of Science and Technology Key Laboratory of Health and Disease Genomics; Chinese National Human Genome Center at Shanghai; Shanghai China

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Science and Technology Commission of Pudong New Area Foundation

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference38 articles.

1. Genetic aberrations in paediatric acute leukaemias and implications for management of patients;Szczepanski;Lancet Oncol,2010

2. Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements;Holland;Nat Med,2012

3. MLL translocations, histone modifications and leukaemia stem-cell development;Krivtsov;Nat Rev Cancer,2007

4. Molecular mechanisms of MLL-associated leukemia;Yokoyama;Int J Hematol,2015

5. Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821;Raimondi;Blood,1999

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