Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features-Reference-Cited by-同舟云学术

Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features

Published:2023-06-09 Issue:8 Volume:45 Page:2017-2027
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Tsai Ming‐Hsien¹²³,Chuang Hui‐Ching¹²⁴^ORCID,Chien Chih‐Yen¹²⁴⁵^ORCID,Huang Tai‐Lin²⁶,Lu Hui¹,Su Yan‐Ye¹²,Yang Chao‐Hui¹²,Lai Chi‐Chih¹²,Tsai Wen‐Ling⁷,Lin Yu‐Tsai¹²³,Fang Fu‐Min²⁴⁸^ORCID

Affiliation:

1. Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

2. Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan

3. College of Pharmacy and Health Care Tajen University Pingtung County Taiwan

4. Department of Medicine Chang Gung University College of Medicine Taoyuan Taiwan

5. Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan

6. Department of Hematology and Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

7. Department of Cosmetics and Fashion Styling, Center for Environmental Toxin and Emerging‐Contaminant Research Cheng Shiu University Kaohsiung Taiwan

8. Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan

Abstract

AbstractBackgroundThe study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features.MethodsIn total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled.ResultsThe optimal LNR cut‐off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016).ConclusionFor HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.

Funder

Chang Gung Memorial Hospital

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27428

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