TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression-Reference-Cited by-同舟云学术

TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression

Published:2022-01 Issue:1 Volume:11 Page:
ISSN:2050-0068
Container-title:Clinical & Translational Immunology
language:en
Short-container-title:Clin & Trans Imm

Author:

Tenshin Hirofumi¹²,Teramachi Jumpei³,Ashtar Mohannad¹,Hiasa Masahiro¹,Inoue Yusuke²,Oda Asuka²,Tanimoto Kotaro¹,Shimizu So¹,Higa Yoshiki¹,Harada Takeshi²,Oura Masahiro²,Sogabe Kimiko²,Hara Tomoyo²,Sumitani Ryohei²,Maruhashi Tomoko²,Sebe Mayu⁴,Tsutsumi Rie⁴,Sakaue Hiroshi⁴,Endo Itsuro⁵,Matsumoto Toshio⁶,Tanaka Eiji¹,Abe Masahiro²^ORCID

Affiliation:

1. Department of Orthodontics and Dentofacial Orthopedics Tokushima University Graduate School of Biomedical Sciences Tokushima Japan

2. Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences Tokushima Japan

3. Department of Oral Function and Anatomy, Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan

4. Department of Nutrition and Metabolism Tokushima University Graduate School of Biomedical Sciences Tokushima Japan

5. Department of Bioregulatory Sciences Tokushima University Graduate School of Biomedical Sciences Tokushima Japan

6. Fujii Memorial Institute of Medical Sciences Tokushima University Tokushima Japan

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

General Nursing,Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cti2.1371

Reference52 articles.

1. Inflammasomes: mechanism of action, role in disease, and therapeutics

2. Critical role for calcium mobilization in activation of the NLRP3 inflammasome

3. Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

4. Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

5. Mechanism and Regulation of NLRP3 Inflammasome Activation

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