Prevention of conversion to abnormal transcranial Doppler with hydroxyurea in sickle cell anemia: A Phase III international randomized clinical trial

Author:

Hankins Jane S.1,McCarville Mary Beth1,Rankine-Mullings Angela2,Reid Marvin E.2,Lobo Clarisse L.C.3,Moura Patricia G.3,Ali Susanna2,Soares Deanne P.2,Aldred Karen2,Jay Dennis W.1,Aygun Banu4,Bennett John5,Kang Guolian1,Goldsmith Jonathan C.6,Smeltzer Matthew P.1,Boyett James M.1,Ware Russell E.7

Affiliation:

1. Department of Hematology; St. Jude Children's Research Hospital; Memphis Tennessee

2. Sickle Cell Unit; Tropical Medicine Research Institute (TMRI), University of the West Indies; Kingston Jamaica

3. Instituto De Hematologia Arthur Siqueira Cavalcanti (HEMORIO); Rio De Janeiro Brazil

4. Division of Pediatric Hematology/Oncology and Stem Cell Transplantation; Cohen Children's Medical Center of New York; New Hyde Park New York

5. Wake Forest University School of Medicine; Winston-Salem North Carolina

6. National Heart Lung and Blood Institute; Bethesda Maryland

7. Division of Hematology; Cincinnati Children's Hospital Medical Center; Cincinnati Ohio

Funder

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Hematology

Reference36 articles.

1. Evaluation of a comprehensive transcranial Doppler screening program for children with sickle cell anemia;McCarville;Pediatr Blood Cancer,2008

2. Implementation of transcranial Doppler ultrasonography screening and primary stroke prevention in urban and rural sickle cell disease populations;Hussain;Pediatr Blood Cancer,2014

3. Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler;Adams;Ann Neurol,1997

4. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography;Adams;N Engl J Med,1998

5. The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anaemia;Hankins;Br J Haematol,2008

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