Transverse interlaminar ultrasound‐guided C1‐C2 puncture for the intrathecal administration of nusinersen in patients with spinal muscular atrophy-Reference-Cited by-同舟云学术

Transverse interlaminar ultrasound‐guided C1‐C2 puncture for the intrathecal administration of nusinersen in patients with spinal muscular atrophy

Published:2024-07-25 Issue: Volume: Page:
ISSN:0148-639X
Container-title:Muscle & Nerve
language:en
Short-container-title:Muscle and Nerve

Author:

Yuan Qing¹^ORCID,Cui Xulei¹,Zhang Jiao¹,Dai Yi²,Feng Feng³,Huang Yuguang¹,Zhang Shuyang⁴

Affiliation:

1. Department of Anesthesiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

2. Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

3. Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

4. State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Abstract

AbstractIntroduction/AimsSevere spinal deformities and previous spinal orthopedic instrumentation may result in substantial technical challenges for nusinersen delivery through lumbar puncture in patients with spinal muscular atrophy (SMA). The aim of this paper was to review our experience with ultrasound‐guided cervical puncture as an alternative approach for the intrathecal administration of nusinersen.MethodsThis was a retrospective medical record review of transverse interlaminar ultrasound‐guided C1‐C2 puncture for nusinersen delivery in SMA patients. The details of puncture, complications, and success rate of the procedure were summarized.ResultsThere were four patients who received a total of 13 cervical punctures for nusinersen delivery. All procedures were technically successful with no major complications. Full doses of nusinersen were delivered intrathecally.DiscussionTransverse interlaminar ultrasound‐guided C1‐C2 puncture is an alternative approach for administering nusinersen if lumbar puncture fails. The success of the technique requires a thorough preprocedural evaluation of cervical spine imaging, sound knowledge of the cervical sonoanatomy and careful manipulation of the needle.

Funder

National Key Research and Development Program of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mus.28212

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