Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

Author:

Rodríguez‐Ramírez Alejandra Monserrat1ORCID,Cedillo‐Ríos Valente2,Sanabrais‐Jiménez Marco Antonio1ORCID,Becerra‐Palars Claudia3,Hernández‐Muñoz Sandra1,Ortega‐Ortíz Hiram3,Camarena‐Medellin Beatriz1ORCID

Affiliation:

1. Departamento de Farmacogenética Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Mexico City Mexico

2. Departamento de Imágenes Cerebrales Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Mexico City Mexico

3. Dirección de Servicios Clínicos Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Mexico City Mexico

Abstract

AbstractValproate is among the most prescribed drugs for bipolar disorder; however, 87% of patients do not report full long‐term treatment response (LTTR) to this medication. One of valproate's suggested mechanisms of action involves the brain‐derived neurotrophic factor (BDNF), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of BDNF in LTTR and its implications in the structure of the dorsolateral prefrontal cortex (dlPFC) is scarce. We explore the association of BDNF variants and dorsolateral cortical thickness (CT) with LTTR to valproate in bipolar disorder type I (BDI). Twenty‐eight BDI patients were genotyped for BDNF polymorphisms rs1519480, rs6265, and rs7124442, and T1‐weighted 3D brain scans were acquired. LTTR to valproate was evaluated with Alda's scale. A logistic regression analysis was conducted to evaluate LTTR according to BDNF genotypes and CT. We evaluated CT differences by genotypes with analysis of covariance. LTTR was associated with BDNF rs1519480 and right dlPFC thickness. Insufficient responders with the CC genotype had thicker right dlPFC than TC and TT genotypes. Full responders reported thicker right dlPFC in TC and TT genotypes. In conclusion, different patterns of CT related to BDNF genotypes were identified, suggesting a potential biomarker of LTTR to valproate in our population.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Genetics (clinical)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3