Affiliation:
1. Department of Obstetrics & Gynecology Baylor College of Medicine Houston Texas USA
2. Maternal Fetal Care Center Boston Children's Hospital Harvard Medical School Boston Massachusetts USA
3. Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome Rome Italy
4. Comprehensive Genetics PLLC New York New York USA
5. Department of Obstetrics & Gynecology Icahn School of Medicine at Mt. Sinai New York New York USA
Abstract
AbstractTo evaluate obstetrical outcomes for women having late amniocentesis (on or after 24 weeks). Electronic databases were searched from inception to January 1st, 2023. The obstetrical outcomes evaluated were gestational age at delivery, preterm birth (PTB) < 37 weeks, PTB within 1 week from amniocentesis, premature prelabor rupture of membranes (pPROM), chorionamnionitis, placental abruption, intrauterine fetal demise (IUFD) and termination of pregnancy (TOP). The incidence of PTB <37 weeks was 4.85% (95% CI 3.48–6.56), while the incidence of PTB within 1 week was 1.42% (95% CI 0.66–2.45). The rate of pPROM was 2.85% (95% CI 1.21–3.32). The incidence of placental abruption was 0.91% (95% CI 0.16–2.25), while the rate of IUFD was 3.66% (95% CI 0.00–14.04). The rate of women who underwent TOP was 6.37% (95%CI 1.05–15.72). When comparing amniocentesis performed before or after 32 weeks, the incidence of PTB within 1 week was 1.48% (95% CI 0.42–3.19) and 2.38% (95% CI 0.40–5.95). Amniocentesis performed late after 24 weeks of gestation is an acceptable option for patients needing prenatal diagnosis in later gestation.
Subject
Genetics (clinical),Obstetrics and Gynecology