Mini Review: Anticancer activity of diterpenoid peroxides

Author:

Sikorsky Tatyana V.1,Ermolenko Ekaterina V.1,Gloriozova Tatyana A.2,Dembitsky Valery M.3

Affiliation:

1. A. V. Zhirmunsky National Scientific Center of Marine Biology Vladivostok 690041 Russia

2. Institute of Biomedical Chemistry Moscow Russia 119121

3. Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College 3000 College Drive South Lethbridge Canada AB T1K 1L6

Abstract

AbstractIn this review, we present about 100 diterpenoid hydro‐ and endoperoxides isolated from algae, liverworts, leaves, bark, roots and other parts of plants. for the vast majority of hydroperoxides, antitumor activity dominates with a confidence of 63 % to 94 %. And for individual hydroperoxides, antiprotozoal (Plasmodium) activity was also found. For endoperoxides, antitumor activity is dominant with a confidence of 59 to 90 percent. Anti‐inflammatory, antibacterial and antifungal activities have also been detected for individual endoperoxides. The data obtained are of interest to pharmacologists, medical professionals, as well as to the pharmaceutical industry.

Publisher

Wiley

Reference107 articles.

1. The chemistry of the diterpenoids

2. E.Fujita. The chemistry on the diterpenoids in 1964 Bull. Inst. Chem. Res. Kyoto Univ. 1965 43(3) 278‐302.

3. Natural halogenated diterpenoids;Dembitsky V. M.;Chem. Sustain. Develop.,2002

4. Diterpenoids of terrestrial origin

5. Diterpenoids of terrestrial origin

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