Affiliation:
1. Pharmacology Department Hai Phong University of Medicine and Pharmacy, Ngo Quyen Haiphong Vietnam
2. Vietnam Academy of Science and Technology Graduate University of Science and Technology Cau Giay Hanoi Vietnam
3. Institute of Marine Biochemistry Vietnam Academy of Science and Technology Cau Giay Hanoi Vietnam
4. Institute of Chemistry Vietnam Academy of Science and Technology Cau Giay Hanoi Vietnam
Abstract
AbstractA phytochemical study of the methanolic extract of Syzygium cerasiforme leaves led to the isolation of seven compounds (1–7). Their chemical structures were identified as benzyl‐6ʹ‐O‐galloyl‐β‐d‐glucopyranoside (1), 3‐methoxy‐4‐hydroxyphenol 1‐O‐β‐D‐(6ʹ‐O‐galloyl)‐glucopyranoside (2), betulonic acid (3), 3‐epi‐betulinic acid (4), 7α‐methoxy‐stigmast‐5‐en‐3β‐ol (5), dihydrodehydrodiconiferyl alcohol (6), and secoisolariciresinol (7), by HR‐ESI‐MS, 1D‐ and 2D NMR spectra, and by comparison with the previously published data. Compounds 1–7 exhibited NO production inhibitory activity in LPS‐activated RAW264.7 cells with IC50 values of 33.17, 25.51, 51.09, 54.17, 39.54, 6.98, and 58.12 µm, respectively, compared to that of the positive control compound, L‐NMMA, which showed an IC50 of 32.5 µm. This is the first report on these compounds from S. cerasiforme.
Funder
Vietnam Academy of Science and Technology