Affiliation:
1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam
2. Institute for Tropical Technology VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam
3. Institute of Materials Science VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam
4. University of Fire Fighting and Prevention 243 Khuat Duy Tien, Thanh Xuan Hanoi 10000 Viet Nam
Abstract
AbstractA phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of five dolabrane‐ (1–5), and ent‐pimarane‐type diterpenoids (6) were isolated from the methanol extract of C. decandra (Griff.) W. Theob. stem barks, via various chromatographic separations. Their structures were elucidated to be ent‐5α,3,15‐dioxodolabr‐1,4(18)‐diene‐2,16‐diol (1), tagalene I (2), ent‐5α,2,15‐dioxodolabr‐3‐ene‐3,16‐diol (3), tagalsin S (4), notolutesin H (5), and ent‐8,15R‐epoxypimaran‐16‐ol (6) by comprehensive analysis of spectroscopic data (1D, 2D NMR, and ESI‐MS data) as well as comparison with the previous literature. All of the isolates were evaluated for their cytotoxicity against human lung cancer (SK‐LU‐1), human hepatocellular carcinoma (HepG2), and human breast cancer (MCF‐7) cell lines. Compounds 2 and 6 exerted inhibitions toward three tumor cell lines (SK‐LU‐1, HepG2, and MCF‐7) with IC50 values between 5.63 and 11.70 μg/mL, while other compounds exhibited weak to moderate or no cytotoxic activities (IC50 > 20 μg/mL).