Affiliation:
1. Collaborative Innovation Center of Biomedical Functional Materials and Key Laboratory of Biofunctional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 P. R. China
2. School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing 211816 P. R. China
Abstract
AbstractIn addition to repressing proliferation, inhibiting the infiltration of tumor cells is an important strategy to improve the treatment of malignant tumors. Herein, a photocatalyst (pCNMC@Pt) is designed by sequentially assembling manganese dioxide, chlorin e6, and platinum (Pt) nanoparticles onto protonated graphitic carbon nitride. With the help of a Z‐scheme structure and near‐infrared (NIR) photosensitizer, pCNMC@Pt is capable of responding to NIR light to generate large amounts of hydrogen (H2). Taking lactic acid in the tumor microenvironment as a sacrificial reagent, H2 therapy initiated by the NIR photocatalyst remarkably impedes the growth of glioblastoma (GBM). More importantly, it is found that H2 can suppress the stemness of glioma stem cells, curbing both proliferation and infiltration of GBM. Furthermore, since pCNMC@Pt and light source are precisely co‐localized through a self‐built loading and illumination system, GBM in mouse brains can be efficiently treated, providing an alternative gas therapy approach to cure infiltrating tumors.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province