The Interplay between Mechanoregulation and ROS in Heart Physiology, Disease, and Regeneration

Author:

Elias‐Llumbet Arturo12,Sharmin Rokshana1,Berg‐Sorensen Kirstine3,Schirhagl Romana1ORCID,Mzyk Aldona3

Affiliation:

1. Department of Biomedical Engineering University of Groningen University Medical Center Groningen Antonius Deusinglaan 1 Groningen 9713AW The Netherlands

2. Laboratory of Genomic of Germ Cells Biomedical Sciences Institute Faculty of Medicine University of Chile Independencia Santiago 1027 Chile

3. DTU Health Tech Ørsteds Plads Bldg 345C Kongens Lyngby 2800 Denmark

Abstract

AbstractCardiovascular diseases are currently the most common cause of death in developed countries. Due to lifestyle and environmental factors, this problem is only expected to increase in the future. Reactive oxygen species (ROS) are a key player in the onset of cardiovascular diseases but also have important functions in healthy cardiac tissue. Here, the interplay between ROS generation and cardiac mechanical forces is shown, and the state of the art and a perspective on future directions are discussed. To this end, an overview of what is currently known regarding ROS and mechanosignaling at a subcellular level is first given. There the role of ROS in mechanosignaling as well as the interplay between both factors in specific organelles is emphasized. The consequences at a larger scale across the population of heart cells are then discussed. Subsequently, the roles of ROS in embryogenesis, pathogenesis, and aging are further discussed, exemplifying some aspects of mechanoregulation. Finally, different models that are currently in use are discussed to study the topics above.

Funder

Novo Nordisk Fonden

Danmarks Frie Forskningsfond

European Commission

Stichting De Cock-Hadders

Publisher

Wiley

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