Macrophage Membrane‐Camouflaged Aggregation‐Induced Emission Nanoparticles Enhance Photodynamic‐Immunotherapy to Delay Postoperative Tumor Recurrence

Author:

Meng Zijuan1,Wang Tingting1,Hu Yuxin1,Ouyang Hanzhi1,Wang Quan1,Wu Meng2,Zhou Jian3,Lou Xiaoding14,Wang Shixuan2,Dai Jun2,Xia Fan14ORCID

Affiliation:

1. Faculty of Materials Science and Chemistry China University of Geosciences Wuhan 430074 P. R. China

2. Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430034 P. R. China

3. College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 311121 P. R. China

4. Zhejiang Institute China University of Geosciences Hangzhou 311305 P. R. China

Abstract

AbstractSurgery is a traditional tumor treatment, and immunotherapy can reduce the postoperative recurrence of tumors. However, the intrinsic limits of low responsive rate and non‐tumor specificity of immunotherapy agents are still insufficient to address therapeutic demands. Herein, the macrophages membrane camouflaged nanoparticles (NPs), named M@PFC, consisting of the aggregation‐induced emission photosensitizer (PF3‐PPh3) and immune adjuvant (CpG), are reported. As the protein on the membrane interacts with the vascular cell adhesion molecule 1 (VCAM‐1) of cancer cells, M@PFC efficiently transports CpG to the tumor. Meanwhile, M@PFC can evade clearance by the immune system and prolong the circulation time in vivo; thus, enhancing their accumulation in tumors. PF3‐PPh3 promotes high production of reactive oxygen species (ROS) and triggers immune cell death (ICD) in tumor cells under light exposure. Importantly, CpG enrichment in tumors can stimulate tumor cells to produce immune factors to assist in enhancing ICD effects. The synergistic effect combining the PDT properties of the aggregation‐induced emission (AIE)‐active photosensitizer and immunotherapy properties of CpG significantly delays tumor recurrence after surgery. In conclusion, this strategy achieves the synergistic activation of the immune system for anti‐tumor activity, providing a novel paradigm for the development of therapeutic nanodrugs to delay postoperative tumor recurrence.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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