Affiliation:
1. Department of Food Science and Technology Zhejiang University of Technology Hangzhou Zhejiang 310014 China
2. Key Laboratory of Food Macromolecular Resources Processing Technology Research (Zhejiang University of Technology) China National Light Industry Hangzhou Zhejiang 310014 China
3. College of Biosystems Engineering and Food Science State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310058 China
4. College of Biotechnology and Bioengineering Zhejiang University of Technology Hangzhou 310014 China
5. Zhejiang Yige Beauty Group Hangzhou 310000 China
Abstract
AbstractDrug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional systems for more effective and sustained topical drug delivery. In this study, carboxymethyl‐modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed for sustained transdermal delivery of liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction and electrostatic interaction. The gel properties can be regulated by substitution degree (DS), and when DS = 18.20 ± 0.67% (CMH2), the gel temperature is 37.8 °C, allowing rapid gelation at body temperature (315 s). Moreover, CMH2 hydrogel has suitable spreadability (17.7–57.2 cm2), viscosity (2133.4 mPa s) and porous structure, which facilitated its adhesion and application on the skin and liposomes delivery. The hydrogel can retard the liposomes release, and the release rate of ascorbyl glucoside (AA2G) is 33.92–49.35% in 24 h. Hydrogel avoids the rapid clearance of liposomes from the skin and improved the skin retention, achieving the long‐term release of bioactive components. Liposome‐hydrogel system more efficiently promotes the anti‐photoaging effect of AA2G on skin, reducing epidermal thickness, melanin deposition and lipid oxidative damage and increasing collagen density. Therefore, liposome‐hydrogel systems are proposed as multifunctional delivery systems for sustained transdermal delivery.
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
2 articles.
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