Affiliation:
1. The Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging Chongqing 400010 China
2. Dianjiang People's Hospital of Chongqing Chongqing 408300 China
3. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
Abstract
AbstractSynergistic photodynamic and photothermal therapy (PDT‐PTT) has emerged as an appealing effective antitumor approach. However, clinical utilization of PDT‐PTT is plagued by aggregation‐caused photobleaching, sequential double irradiations, unsatisfying balance between single oxygen (1O2) quantum yield and photothermal conversion efficiency. Here, an anchored tumor‐homing cell‐penetrating peptide (PEGA‐pVEC) and PANI‐ES/HMME loaded FRET nanobullet (AHP‐P) are reported. Within nanobullet, HMME (donor) and PANI‐ES (acceptor) spontaneously form a förster resonance energy transfer (FRET) pair. Upon 660 nm laser irradiation, HMME convert near‐infrared fluorescence (NIRF) to PANI, thus produce FRET‐amplified photoacoustic imaging guided PTT. In addition, AHP‐P with pH‐sensitivity can gradually release HMME within acidic tumor environment, boosts the 1O2 regeneration alongside with highly efficient photothermal conversion for photoinduced cancer PTT‐PDT. Furthermore, the AHP‐P nanobullet can home in on the tumor site and penetrate into cytoplasm through PEGA‐pVEC, inducing remarkable tumor regression with an ≈80% tumor volume reduction and decreased skin phototoxicity in vivo during FRET‐amplified PTT‐PDT.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Chongqing Postdoctoral Science Foundation
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
4 articles.
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