Affiliation:
1. Polymeric and Soft Materials Laboratory Advanced Institute of Materials Science School of Chemical Engineering Changchun University of Technology Changchun 130012 P. R. China
2. Department of Hand Surgery The Second Hospital of Jilin University Changchun 130041 P. R. China
3. Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin University Changchun Jilin 130041 P. R. China
Abstract
AbstractSelf‐pumping dressings become one of the optimal solutions for the controlled management of chronic diabetic wound exudate and wound healing. However, present self‐pumping dressings are not only prone to breakage of the loose hydrophobic layer but also have cumbersome and complicated preparation steps, which hinder the application of self‐pumping dressings in diabetic wound treatment. Herein, a novel self‐pumping structure of superabsorbent Janus dressing is designed to improve the strength of the hydrophobic layer and promote diabetic wound healing. The Janus dressing consists of a hydrophobic layer with a drainage agent (drainage layer) and a fluffy 3D nanofiber cotton (absorbent layer). Regardless of the thickness of the drainage layer, the drainage agent in the drainage layer provides the fluid to penetrate the drainage layer to the absorbent layer for unidirectional fluid draining. In design proof, the superabsorbent Janus dressing provides unidirectional drainage of inflammatory exudate and regulation of macrophage polarization, resulting in faster diabetic wound healing than single‐layer dressings. Thus, the Janus dressing demonstrates important clinical implications to offer a novel design and preparation strategy for accelerating diabetic wound healing.
Funder
Jilin Provincial Scientific and Technological Development Program
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
1 articles.
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