Affiliation:
1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University Shanghai 201620 P. R. China
2. School of Environmental Science and Engineering Donghua University Shanghai 201620 P. R. China
Abstract
AbstractCombination of platinum(II) metallacycles and photodynamic inactivation presents a promising antibacterial strategy. Herein, a cascaded artificial light‐capturing system is developed in which an aggregation‐induced emission‐active platinum(II) metallacycle (PtTPEM) is utilized as the antenna, sulforhodamine 101 (SR101) as a key conveyor, and the near‐infrared emissive photosensitizer Chlorin‐e6 (Ce6) as the final energy acceptor. The well‐dispersed Ce6 in the proximity of energy donors not only avoids self‐quenching in the physiological environment but also contributes to energy transfer from donor to acceptor, thereby significantly improving the 1O2 generation ability of the light‐harvesting system under white light irradiation. By integrating the platinum(II) metallacycle and 1O2, a more efficient synergistic antibacterial effect is achieved at low concentrations, along with a significant decrease in dark toxicity caused by PtTPEM.
Funder
Natural Science Foundation of Shanghai Municipality
Fundamental Research Funds for the Central Universities
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
3 articles.
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