A Drop‐By‐Drop Self‐Assembled All‐Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity

Author:

Gao Wanshan1,Liu Yang2,Li Mingjing23,Ding Mingming2,Cheng Li4,Ding Chunmei2,Yang Jiaojiao4,Li Jianshu245ORCID,Luo Jun2ORCID,Qiu Rongmin1ORCID

Affiliation:

1. College of Stomatology Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Clinical Research Center for Craniofacial Deformity Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases Nanning 530021 P. R. China

2. College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 P. R. China

3. Department of Medical Engineering the Second Affiliated Hospital of Army Medical University Chongqing 400037 P. R. China

4. State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 610041 P. R. China

5. Med‐X Center for Materials Sichuan University Chengdu 610041 P. R. China

Abstract

AbstractDentin hypersensitivity (DH) is a prevalent dental condition arising from the exposure of dentin tubules (DTs), leading to discomfort upon external stimuli. However, achieving swift and profound occlusion of these exposed DTs for immediate and enduring relief remains challenging due to the intricate dentin structure and oral environment. Herein, a pioneering and facile drop‐by‐drop strategy involving an in situ generated natural supramolecular hydrogel formed by self‐assembling silk fibroin (SF) and tannic acid (TA) within the narrow DT space is proposed. When SF and TA aqueous solutions are applied successively to exposed dentin, they penetrate deeply within DTs and coassemble into compact gels, robustly adhering to DT walls. This yields a rapid and compact occlusion effect with an unprecedented depth exceeding 250 µm, maintaining stable occlusion efficacy even under rigorous in vitro and in vivo erosion and friction conditions for no less than 21 days. Furthermore, the biocompatibility and effective occlusion properties are verified through cell studies in simulated oral settings and an in vivo rabbit model. This study, for the first time, demonstrates the translational potential of hydrogel‐based desensitizers in treating DH with prompt action, superior occlusion depth and enduring treatment benefits, holding promise as clinical‐friendly restorative solutions for delicate‐structured biosystems.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Increasing the efficiency of gene editing with CRISPR-Cas9 via concurrent expression of the Beta protein;International Journal of Biological Macromolecules;2024-06

2. Research Progress in Hydrogels for Cartilage Organoids;Advanced Healthcare Materials;2024-05-27

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