Affiliation:
1. Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐based Functional Materials and Devices Soochow University Suzhou Jiangsu 215123 China
2. Department of Orthopedics The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215123 China
3. Department of Orthopedics The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui 233004 China
Abstract
AbstractHow to promote wound healing is still a major challenge in the healthcare while macrophages are a critical component of the healing process. Compared to various bioactive drugs, many plants have been reported to facilitate the wound healing process by regulating the immune response of wounds. In this work, a 3D printed hydrogel scaffold loaded with natural Centella asiatica extract (CA extract) is developed for wound healing. This CA@3D scaffold uses gelatin and sodium alginate with CA extract as bio‐ink for 3D printing. The CA extract contains a variety of bioactive compounds that make the various active ingredients in Centella asiatica work in concert. The printed CA@3D scaffold can fit the shape of wound, orchestrate the macrophages and immune responses within the wound, and promote wound healing compared to commercial wound dressings. The underlying mechanism of promoting wound healing was also illuminated by applying multi‐omic analyses. Moreover, the CA extract loaded 3D scaffold also showed great ability to promote wound healing in diabetic chronic wounds. Due to its ease of preparation, low‐cost, biosafety, and therapeutic outcomes, this work proposes an effective strategy for promoting chronic wound healing.This article is protected by copyright. All rights reserved
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials