Affiliation:
1. Laboratory of Molecular Imaging Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital) Taiyuan 030000 China
2. Department of Orthopedics Third Hospital of Shanxi Medical University Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital Taiyuan 030032 China
Abstract
AbstractDespite advancements in breast cancer treatment, bone metastases remain a significant concern for advanced breast cancer patients. Current theranostics strategies face challenges in integrating tumor theranostics and bone formation. Herein, this work develops an activatable targeted nanomedicine AuMnCO@BSA‐N3 (AMCBN) to enable a novel collaborative integration of second near‐infrared (NIR‐II) fluorescence imaging guided precise theranostics for breast cancer bone metastases and osteogenic microenvironment remolding. This strategy employs a chemical coordination between noble metal complex and metal carbonyl (MnCO), with surface modification of azide groups to enhance tumor affinity through passive and active targeting. The initiated respondent behavior of AMCBN by tumor microenvironment accelerate the degradation of coordinated MnCO, resulting in a rapid release of multifunctional agents for efficient chemodynamic therapy (CDT)/gas synergistic therapy. Meanwhile, the exceptional bone‐binding properties enable the efficient and controlled release of Mn2+ ions and carbon monoxide (CO) in the bone microenvironment, thereby facilitating the expression of osteogenesis‐related proteins and establishing a novel synchronous theranostics process for tumor‐bone repair.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Shanxi Scholarship Council of China
Shanxi Province Science Foundation for Youths
National Ten Thousand Talent Program
Cited by
1 articles.
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