Affiliation:
1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310058 P. R. China
2. State Key Laboratory of Transvascular Implantation Devices The Second Affiliated Hospital Zhejiang University School of Medicine 88 Jiefang Rd Hangzhou 311202 P. R. China
Abstract
AbstractThe foreign body response (FBR) is an immune‐mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that consistently hampers their optimal utilization. Over the last decade, significant strides are achieved based on either hydrogel design or surface modifications to mitigate the FBR. This review delves into recent material strategies aimed at mitigating the FBR. Further, the authors look forward to future novel anti‐FBR materials from the perspective of clinical translation needs. Such prospective materials hold the potential to attenuate local immune responses, thereby significantly enhancing the overall performance of implantable devices.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Zhejiang University
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