Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Author:

Fontana Flavia1,Molinaro Giuseppina1,Moroni Sofia12,Pallozzi Giulia13,Ferreira Mónica P. A.1,Tello Rubén Pareja1,Elbadri Khalil1,Torrieri Giulia1,Correia Alexandra1,Kemell Marianna4,Casettari Luca2,Celia Christian356,Santos Hélder A.17ORCID

Affiliation:

1. Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland

2. Department of Biomolecular Sciences School of Pharmacy University of Urbino Carlo Bo Urbino I‐61029 Italy

3. Department of Pharmacy University of Chieti‐Pescara “G. D'Annunzio” Via dei Vestini 13 Chieti I‐66100 Italy

4. Department of Chemistry University of Helsinki Helsinki FI‐00014 Finland

5. Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 P. R. China

6. Laboratory of Drug Targets Histopathology Institute of Cardiology Lithuanian University of Health Sciences Kaunas LT‐44307 Lithuania

7. Department of Biomaterials and Biomedical Technology University Medical Center Groningen, University of Groningen Groningen 9713 AV The Netherlands

Abstract

AbstractAtherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation of lipids in the plaque, inflammation is recognized as one of the key players in the formation and development of atherosclerotic plaque. Systemic anti‐inflammatory treatments are successful in reducing the disease burden, but are correlated with severe side effects, underlining the need for targeted formulations. In this work, curcumin is chosen as the anti‐inflammatory payload model and further loaded in lignin‐based nanoparticles (NPs). The NPs are then coated with a tannic acid (TA)− Fe (III) complex and further cloaked with fragments derived from platelet cell membrane, yielding NPs with homogenous size. The two coatings increase the interaction between the NPs and cells, both endothelial and macrophages, in steady state or inflamed status. Furthermore, NPs are cytocompatible toward endothelial, smooth muscle and immune cells, while not inducing immune activation. The anti‐inflammatory efficacy is demonstrated in endothelial cells by real‐time quantitative polymerase chain reaction and ELISA assay where curcumin‐loaded NPs decrease the expression of Nf‐κb, TGF‐β1, IL‐6, and IL‐1β in lipopolysaccharide‐inflamed cells. Overall, due to the increase in the cell−NP interactions and the anti‐inflammatory efficacy, these NPs represent potential candidates for the targeted anti‐inflammatory treatment of atherosclerosis.

Funder

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Business Finland

Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta

Erasmus+

Publisher

Wiley

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3