Affiliation:
1. School of Pharmacy Nantong University Nantong Jiangsu Province 226001 China
2. Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China
3. Department of General Surgery Zhongshan Hospital Fudan University Shanghai 200032 China
4. Interdisciplinary Research Center in Biomedical Materials COMSATS University Islamabad Lahore Campus Lahore 54000 Pakistan
Abstract
AbstractVaccination immunotherapy has revolutionized cancer treatment modalities. Although the immunomodulatory adjuvant generally employs for potentiating vaccine response, systemic administration may drive immune‐related side effects, even immune tolerance. Therefore, tunable immunoadjuvants are highly desirable to simultaneously stimulate the immune response and mitigate systemic toxicity. Self‐immolated nanoadjuvants are herein reported to potentiate vaccination immunotherapy of cancer. The nanoadjuvants are engineered by co‐assembling an intracellular acidity‐ionizable polymeric agonist of toll‐like receptor 7/8 resiquimod (R848) and polymeric photosensitizer pyropheophorbide a (PPa). The resultant nanoadjuvants specifically accumulate at the tumor site via passive targeting and are dissociated in the acidic endosome versicles to activate PPa via protonation of the polymer backbone. Upon 671 nm laser irradiation, PPa performed photodynamic therapy to induce immunogenic cell death of tumor cells and subsequently releases R848 in a customized manner, which synergistically activates dendritic cells (DCs), promotes antigen cross‐presentation, and eventually recruits cytotoxic T lymphocytes for tumor regression. Furthermore, the synergistic in situ vaccination immunotherapy with immune checkpoint blockade induce sustained immunological memory to suppress tumor recurrence in the rechallenged colorectal tumor model.
Funder
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials