Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability

Author:

Lan Xinmiao12ORCID,Zhong Jie234ORCID,Huang Regina5,Liu Yuhan6,Ma Xiaowei7,Li Xuan5,Zhao Dan8,Qing Guangchao3,Zhang Yuxuan34,Liu Lu34,Wang Jinjin34,Ma Xu34,Luo Ting3,Guo Weisheng3,Wang Yuji1ORCID,Li Li‐Li34ORCID,Su Yu‐Xiong2ORCID,Liang Xing‐Jie34ORCID

Affiliation:

1. Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, School of Pharmaceutical Science Capital Medical University Beijing 100069 China

2. Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry The University of Hong Kong Hong Kong SAR 999077 China

3. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China

4. University of Chinese Academy of Sciences Beijing 100049 China

5. Discipline of Periodontology, Faculty of Dentistry The University of Hong Kong Hong Kong SAR 999077 China

6. Department of Stomatology, Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine Chinese Academy of Science Beijing 100012 China

7. National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine China Agricultural University Beijing 100193 China

8. Beijing Institute of Dental Research, Beijing Stomatological Hospital Capital Medical University Beijing 100069 China

Abstract

AbstractAntimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms. With in‐depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self‐assembled properties have gradually become a hot research topic for various biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self‐assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, four self‐assembled AMPs are developed, and the relationship between their chemical structures and antibacterial activity is explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self‐assembled AMPs in subsequent treatments for combating bacterial infections.

Funder

National Key Research and Development Program of China

Beijing Municipal Commission of Education

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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