Affiliation:
1. Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat‐sen University Guangzhou Guangdong 510055 P. R. China
2. Laboratory of Biomaterials Key Laboratory on Assisted Circulation Ministry of Health Cardiovascular Division First Affiliated Hospital Sun Yat‐sen University Guangzhou Guangdong 510080 P. R. China
Abstract
AbstractReducing the burden of death due to wound infection is an urgent global public health priority. Metal‐phenolic networks (MPNs) have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and antimicrobial properties brought about by polyphenols and metal ions. However, typical therapeutic MPNs show rapid release of metal ions due to their poor solution stability, impeding long‐acting efficacy in multiple wound healing stages. To address these issues, copper‐poly (tannic acid) nanoparticles (Cu‐PTA NPs): robust (dually crosslinked), microenvironment‐responsive, antibacterial, antioxidative, and anti‐inflammatory are prepared, which hierarchically modulate the infected wound healing process. Covalently polymerized via phenol‐formaldehyde condensation and crosslinked with bioactive Cu2+, reactive polyphenols are preserved, and Cu2+ is efficiently entrapped in the PTA scaffold. The proposed strategy relieves the systemic toxicity, and only high reactive oxygen species (ROS)level as stimuli can “turn on” the catalytic activity of Cu2+ to implement antibacterial therapy specifically in an infected wound. Systematic tissue regeneration assessment on the infected full‐thickness skin wounds of rats demonstrates enhanced wound healing rate. Cu‐PTA NPs enables the direct application in infected wound and exertion of long‐acting healing efficacy. This synergetic therapy strategy will pave the way for more complicated infections and inflammatory diseases.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
14 articles.
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