Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade

Author:

Guan Dong-Xian1,Shi Jie2,Zhang Yang3,Zhao Jiang-Sha1,Long Ling-Yun1,Chen Tian-Wei1,Zhang Er-Bin1,Feng Yuan-Yuan1,Bao Wen-Dai1,Deng Yue-Zhen1,Qiu Lin1,Zhang Xue-Li4,Koeffler H. Phillip56,Cheng Shu-qun2,Li Jing-Jing1,Xie Dong1

Affiliation:

1. Laboratory of Molecular Oncology; Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai China

2. Eastern Hepatobiliary Surgery Hospital; Second Military Medical University; Shanghai China

3. The Second Hospital of Anhui Medical University; Hefei China

4. Department of General Surgery of FenXian Hospital; Shanghai China

5. Cancer Science Institute of Singapore; National University of Singapore; Singapore

6. Division of Hematology/Oncology, Cedars-Sinai Medical Center; UCLA School of Medicine; Los Angeles CA

Funder

Ministry of Science and Technology Key Program

National Natural Science Foundation of China

CAS/SAFEA International Partnership Program for Creative Research Teams

Chief Scientist Program, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Publisher

Wiley

Subject

Hepatology

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