Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer

Author:

Isaacs John T.,D'Antonio Jason M.,Chen Shuangling,Antony Lizamma,Dalrymple Susan P.,Ndikuyeze Georges H.,Luo Jun,Denmeade Samuel R.

Funder

NIH

NIH Prostate SPORE

The Maryland Stem Cell Research Fund

The One-in-Six Foundation, Akron, OH

Urology Training Grant NIH

Publisher

Wiley

Subject

Urology,Oncology

Reference45 articles.

1. Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?;Litvinov;J Clin Endocrinol Metab,2003

2. Androgen Receptor (AR) suppresses human prostate epithelial cell proliferation via AR/β-Catenin/TCF-4 complex inhibition of c-Myc transcription;Vander Griend;PLos-one,2012

3. Abiraterone and increased survival in metastatic prostate cancer;Bono;N Engl J Med,2011

4. Molecular determinants of resistance to antiandrogen therapy;Chen;Nat Med,2004

5. Androgen-independent prostate cancer is a heterogeneous group of diseases: Lessons from a rapid autopsy program;Shah;Cancer Res,2004

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