Affiliation:
1. Friedrich-Schiller-Universität Institut für Organische Chemie und Makromolekulare Chemie Humboldtstr. 10 07743 Jena Germany
2. Friedrich-Schiller-Universität Institut für Anorganische und Analytische Chemie Humboldtstr. 8 07743 Jena Germany
Abstract
AbstractMethanobactin OB3b (Mbn‐OB3b) is a unique natural product with stunning affinity for copper ions (Ka≈Cu(I) 1034). Here, we report the first total synthesis of Cu(I)‐bound methanobactin OB3b featuring as key transformations a cyclodehydration‐thioacylation sequence, to generate the conjugated heterocyclic systems, and a copper‐templated cyclization, to complete the caged structure of the very sensitive target compound.
Funder
Deutsche Forschungsgemeinschaft
Freistaat Thüringen
Sapienza Università di Roma
Subject
General Chemistry,Catalysis