Affiliation:
1. Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences State Key Laboratory of Rare Earth Resource Utilization 5625 Renmin Street 130022 Changchun CHINA
2. Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences State Key Laboratory of Rare Earth Resource Utilization CHINA
3. Changchun Institute of Applied Chemistry Chinese Academy of Sciences: Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street 130022 Changchun CHINA
Abstract
Pyroptosis is an effective anti‐tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable monometallic Al can as a pyroptosis biotuner for tumor therapy. pH‐sensitive Al nanoparticles (Al@P) are obtained by equipping polyethylene glycol‐b‐(poly(methyl methacrylate)‐co‐poly(4‐vinylpyridine), which can exert their effect at the tumor site without affecting normal cells. The H2 and Al3+ release by Al@P in the acidic environment of tumor disrupts the redox balance and ionic homeostasis in tumor cells, thus generating large amounts of reactive oxygen species (ROS), leading to caspase‐1 activation, gasdermin D cleavage, and IL‐1β/LDH release, which induces canonical pyroptotic death. Meanwhile, prodrug Doxorubicin (Pro‐DOX) is successfully loaded onto Al@P (Al@P‐P) and can be activated by ROS to release DOX in the tumor cells, thus further improving the tumor‐killing efficiency. Ultimately, Al@P‐P has degradability and exhibits efficient tumor inhibition.
Subject
General Chemistry,Catalysis