An Electrochemical Nanosensor for Monitoring the Dynamics of Intracellular H2O2 Upon NADH Treatment

Author:

Zhang Shuai1,Qin Hancheng1,Cheng Shuwen1,Zhang Yue1,Gao Nan1,Zhang Meining1ORCID

Affiliation:

1. Department of Chemistry Renmin University of China Beijing 100872 China

Abstract

AbstractReactive oxygen species (ROS)‐based therapeutic strategies play an important role in cancer treatment. However, in situ, real‐time and quantitative analysis of intracellular ROS in cancer treatment for drug screening is still a challenge. Herein we report one selective hydrogen peroxide (H2O2) electrochemical nanosensor, which is prepared by electrodeposition of Prussian blue (PB) and polyethylenedioxythiophene (PEDOT) onto carbon fiber nanoelectrode. With the nanosensor, we find that the level of intracellular H2O2 increases with NADH treatment and that increase is dose‐dependent to the concentration of NADH. High‐dose of NADH (above 10 mM) can induce cell death and intratumoral injection of NADH is validated for inhibiting tumor growth in mice. This study highlights the potential of electrochemical nanosensor for tracking and understanding the role of H2O2 in screening new anticancer drug.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Catalysis

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