Affiliation:
1. Center of Chemistry for Frontier Technologies Department of Chemistry Zhejiang University Hangzhou 310027 China
2. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 China
Abstract
AbstractHighly efficient synthesis of axially chiral biaryl amines through cobalt‐catalyzed atroposelective C−H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl‐2‐amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Zhejiang Province
China Postdoctoral Science Foundation
Subject
General Chemistry,Catalysis
Cited by
10 articles.
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