Affiliation:
1. Stratingh Institute for Chemistry University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands
2. Chemical and Pharmaceutical Biology Groningen Research Institute of Pharmacy University of Groningen A. Deusinglaan 1 9713 AV Groningen The Netherlands
3. Department of Radiology Medical Imaging Center University of Groningen University Medical Center Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands
Abstract
AbstractPhotopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into the structure of biologically active small molecules to allow for the optical control of their potency. Going beyond trial and error, photopharmacology has progressively applied rational drug design methodologies to devise light‐controlled bioactive ligands. In this review, we categorize photopharmacological efforts from the standpoint of medicinal chemistry strategies, focusing on diffusible photochromic ligands modified with photoswitches that operate through E‐Z bond isomerization. In the vast majority of cases, photoswitchable ligands are designed as analogs of existing compounds, through a variety of approaches. By analyzing in detail a comprehensive list of instructive examples, we describe the state of the art and discuss future opportunities for rational design in photopharmacology.
Funder
Horizon 2020 Framework Programme
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Subject
General Chemistry,Catalysis
Cited by
21 articles.
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