A Photoisomerizable Zinc (II) Complex Inhibits Microtubule Polymerization for Photoactive Therapy

Author:

Cao Fengshu12,Wang Haobing1,Lu Nong1,Zhang Pingyu1ORCID,Huang Huaiyi2

Affiliation:

1. College of Chemistry and Environmental Engineering Shenzhen University Shenzhen 518060 China

2. School of Pharmaceutical Science (Shenzhen) Shenzhen campus of Sun Yat-sen University No.66, Gongchang Road Shenzhen 518107 China

Abstract

AbstractThe photoisomerization‐induced cytotoxicity in photopharmacology provides a unique pathway for phototherapy because it is independent of endogenous oxygen. In this study, we developed a biosafe photoisomerizable zinc(II) complex (Zn1), which releases its trans ligand (trans‐L1) after being irradiated with blue light. This causes the complex to undergo photoisomerization and produce the toxic cis product (cis‐L1) and generate singlet oxygen (1O2). The resulting series of events caused impressive phototoxicity in hypoxic A431 skin cancer cells, as well as in a tumor model in vivo. Interestingly, Zn1 was able to inhibit tumor microtubule polymerization, while still showing good biocompatibility and biosafety in vivo. This photoisomerizable zinc(II) complex provides a novel strategy for addressing the oxygen‐dependent limitation of traditional photodynamic therapy.

Funder

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Wiley

Subject

General Chemistry,Catalysis

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