An Intelligent DNA Nanoreactor for Easy‐to‐Read In Vivo Tumor Imaging and Precise Therapy

Author:

Mao Dongsheng12,Dong Ziliang2,Liu Xueliang2,Li Wenxing1,Li Hongyi2,Gu Chao2,Chen Ganghui2,Zhu Xiaoli1,Yang Yu2ORCID

Affiliation:

1. Department of Clinical Laboratory Medicine Shanghai Tenth People's Hospital of Tongji University 200072 Shanghai P. R. China

2. Institute of Molecular Medicine (IMM) Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Renji Hospital School of Medicine Shanghai Jiao Tong University 200127 Shanghai P. R. China

Abstract

AbstractNanomaterial‐based in vivo tumor imaging and therapy have attracted extensive attention; however, they suffer from the unintelligent “always ON” or single‐parameter responsive signal output, substantial off‐target effects, and high cost. Therefore, achieving in vivo easy‐to‐read tumor imaging and precise therapy in a multi‐parameter responsive and intelligent manner remains challenging. Herein, an intelligent DNA nanoreactor (iDNR) was constructed following the “AND” Boolean logic algorithm to address these issues. iDNR‐mediated in situ deposition of photothermal substance polydopamine (PDA) can only be satisfied in tumor tissues with abundant membrane protein biomarkers “AND” hydrogen peroxide (H2O2). Therefore, intelligent temperature‐based in vivo easy‐to‐read tumor imaging is realized without expensive instrumentation, and its diagnostic performance matches with that of flow cytometry, and photoacoustic imaging. Moreover, precise photothermal therapy (PTT) of tumors could be achieved via intelligent heating of tumor tissues. The precise PTT of primary tumors in combination with immune checkpoint blockade (ICB) therapy suppresses the growth of distant tumors and inhibits tumor recurrence. Therefore, highly programmable iDNR is a powerful tool for intelligent biomedical applications.

Funder

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Catalysis

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