Affiliation:
1. Department of Bioengineering University of California Riverside Riverside California USA
Abstract
AbstractPurposeBackground suppression (BS) is recommended in arterial spin labeling (ASL) for improved SNR but is difficult to optimize in existing velocity‐selective ASL (VSASL) methods. Dual‐module VSASL (dm‐VSASL) enables delay‐insensitive, robust, and SNR‐efficient perfusion imaging, while allowing efficient BS, but its optimization has yet to be thoroughly investigated.MethodsThe inversion effects of the velocity‐selective labeling pulses, such as velocity‐selective inversion (VSI), can be used for BS, and were modeled for optimizing BS in dm‐VSASL. In vivo experiments using dual‐module VSI (dm‐VSI) were performed to compare two BS strategies: a conventional one with additional BS pulses and a new one without any BS pulse. Their BS performance, temporal noise, and temporal SNR were examined and compared, with pulsed and pseudo‐continuous ASL (PASL and PCASL) as the reference.ResultsThe in vivo experiments validated the BS modeling. Strong positive linear correlations (r > 0.82, p < 0.0001) between the temporal noise and the tissue signal were found in PASL/PCASL and dm‐VSI. Optimal BS can be achieved with and without additional BS pulses in dm‐VSI; the latter improved the ASL signals by 8.5% in gray matter (p = 0.006) and 12.2% in white matter (p = 0.014) and tended to provide better temporal SNR. The dm‐VSI measured significantly higher ASL signal (p < 0.016) and temporal SNR (p < 0.018) than PASL and PCASL. Complex reconstruction was found necessary with aggressive BS.ConclusionGuided by modeling, optimal BS can be achieved without any BS pulse in dm‐VSASL, further improving the ASL signal and the SNR performance.
Funder
National Institutes of Health
Subject
Radiology, Nuclear Medicine and imaging