Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction-Reference-Cited by-同舟云学术

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

Published:2023-10-27 Issue:4 Volume:2 Page:
ISSN:2751-1871
Container-title:Smart Medicine
language:en
Short-container-title:Smart Medicine

Author:

Hu Yangnan¹²,Fang Le³,Zhang Hui¹^ORCID,Zheng Shasha¹,Liao Menghui¹,Cui Qingyue¹,Wei Hao⁴,Wu Danqi¹,Cheng Hong¹,Qi Yanru¹,Wang Huan⁵^ORCID,Xin Tao⁶⁷,Wang Tian⁸⁹,Chai Renjie¹²¹⁰¹¹¹²^ORCID

Affiliation:

1. State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High‐Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing China

2. Co‐Innovation Center of Neuroregeneration Nantong University Nantong China

3. Department of Neurology The China‐Japan Union Hospital of Jilin University Changchun Jilin China

4. Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical School Jiangsu Provincial Key Medical Discipline Nanjing China

5. The Eighth Affiliated Hospital Sun Yat‐Sen University Shenzhen China

6. Department of Neurosurgery The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China

7. Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China

8. Department of Otolaryngology‐Head and Neck Surgery Stanford University School of Medicine Stanford California USA

9. Department of Otolaryngology‐Head and Neck Surgery The Second Xiangya Hospital Central South University Changsha Hunan Province China

10. Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

11. Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing China

12. Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical University Beijing China

Abstract

AbstractHearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/SMMD.20230021

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