Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care

Author:

Candy Bridget1,Jones Louise1,Vickerstaff Victoria1,Larkin Philip J2,Stone Patrick1

Affiliation:

1. Marie Curie Palliative Care Research Department, Division of Psychiatry; University College London; London UK

2. UCD School of Nursing, Midwifery and Health Systems and Our Lady's Hospice and Care Services; UCD College of Health Sciences; Dublin Ireland

Publisher

Wiley

Subject

Pharmacology (medical)

Reference89 articles.

1. A randomized, double-blind, active- controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain;Ahmedzai;Palliative Medicine,2012

2. Center for Drug Evaluation and Research Medical Review Application number: 205777Orig1s000 www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205777Orig1s000MedR.pdf

3. Center for Drug Evaluation and Research Risk Assessment and Risk Mitigation Review. Product oxycodone/naloxone extended-release tablets www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205777Orig1s000RiskR.pdf

4. Fixed-dose subcutaneous methylnaltrexone in patients with advanced illness and opioid-induced constipation: results of a randomized, placebo-controlled study and open-label extension;Bull;Journal of Palliative Medicine.,2015

5. A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone/naloxone (up to 160/80 mg daily) vs oxycodone PR;Dupoiron;European Journal of Pain.,2017

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