Complement inhibitors for age-related macular degeneration

Author:

Tzoumas Nikolaos12,Riding George34,Williams Michael A5,Steel David HW12

Affiliation:

1. Biosciences Institute; Newcastle University; Newcastle-upon-Tyne UK

2. Sunderland Eye Infirmary; Sunderland UK

3. Biosciences Institute, Newcastle University; Newcastle-upon-Tyne UK

4. North Middlesex University Hospital NHS Trust; London UK

5. School of Medicine, Dentistry and Biomedical Science, Queen’s University of Belfast; Belfast UK

Publisher

Wiley

Subject

Pharmacology (medical)

Reference174 articles.

1. Csaky KG Westby K Rezaei K Avacincaptad pegol, a novel C5 inhibitor, significantly reduces the mean rate of geographic atrophy growth in a pivotal clinical trial Investigative Ophthalmology and Visual Science 2020 61 7 ARVO E abstract 1943

2. C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial;Jaffe;Ophthalmology,2021

3. Sheth V Avacincaptad pegol, a novel C5 inhibitor, demonstrates a continued reduction in the mean rate of geographic atrophy growth: 18-month results from the GATHER1 clinical trial Investigative Ophthalmology and Visual Science 2021 62 8 ARVO E abstract 333

4. CLG561 proof-of-concept study as a monotherapy and in combination with LFG316 in subjects with geographic atrophy (GA) clinicaltrials.gov/ct2/show/NCT02515942

5. Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration;Garcia Filho;Ophthalmic Surgery, Lasers and Imaging Retina,2014

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