Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction
Author:
Affiliation:
1. Murdoch Childrens Research Institute and University of Melbourne; Parkville; Victoria; Australia
2. Murdoch Childrens Research Institute; Parkville; Victoria; Australia
3. University of Sydney; St. Leonards; New South Wales; Australia
Publisher
Wiley
Subject
Pharmacology (medical),Immunology,Rheumatology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/art.37900/fullpdf
Reference56 articles.
1. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro;Stanton;Nature,2005
2. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis;Glasson;Nature,2005
3. Transcriptome analysis reveals specific changes in osteoarthritis synovial fibroblasts;Del Rey;Ann Rheum Dis,2012
4. Analysis of meniscal degeneration and meniscal gene expression;Sun;BMC Musculoskelet Disord,2010
5. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis;Karlsson;Osteoarthritis Cartilage,2010
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