Affiliation:
1. Cancer Survival Group Department of Non‐Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine London WC1E 7HT Greater London United Kingdom
2. Department of Radiology Radiotherapy and Oncology Northern State Medical University, Arkhangelsk Arkhangelsk Oblast Russia
3. Croatian National Cancer Registry Croatian Institute of Public Health, Zagreb Zagreb County Croatia
4. Bremen Cancer Registry Bremen Bremen Germany
5. Tuscany Cancer Registry Istituto per lo studio e la prevenzione oncologica Florence Tuscany Italy
6. Cancer Division University College London Hospitals NHS Foundation Trust, London NW1 2BU Greater London United Kingdom
Abstract
AbstractBackgroundEsophageal cancer survival is poor worldwide, though there is some variation. Differences in the distribution of anatomical sub‐site and morphological sub‐type may help explain international differences in survival for all esophageal cancers combined. We estimated survival by anatomic sub‐site and morphological sub‐type to understand further the impact of topography and morphology on international comparisons of esophageal cancer survival.MethodsWe estimated age‐standardized one‐year and five‐year net survival among adults (15‐99 years) diagnosed with esophageal cancer in each of 60 participating countries to monitor survival trends by calendar period of diagnosis (2000‐2004, 2005‐2009, 2010‐2014), sub‐site, morphology, and sex.ResultsFor adults diagnosed during 2010‐2014, tumors in the lower third of the esophagus were the most common, followed by tumors of overlapping sub‐site and sub‐site not otherwise specified. The proportion of squamous cell carcinomas diagnosed during 2010‐2014 was generally higher in Asian countries (50%‐90%), while adenocarcinomas were more common in Europe, North America and Oceania (50%‐60%). From 2000‐2004 to 2010‐2014, the proportion of squamous cell carcinoma generally decreased, and the proportion of adenocarcinoma increased. Over time, there were few improvements in age‐standardized five‐year survival for each sub‐site. Age‐standardized one‐year survival was highest in Japan for both squamous cell carcinoma (67.7%) and adenocarcinoma (69.0%), ranging between 20%‐60% in most other countries. Age‐standardized five‐year survival from squamous cell carcinoma and adenocarcinoma was similar for most countries included, around 15%‐20% for adults diagnosed during 2010‐2014, though international variation was wider for squamous cell carcinoma. In most countries, survival for both squamous cell carcinoma and adenocarcinoma increased by less than 5% between 2000‐2004 and 2010‐2014.ConclusionsEsophageal cancer survival remains poor in many countries. The distributions of sub‐site and morphological sub‐type vary between countries, but these differences do not fully explain international variation in esophageal cancer survival.
Funder
Centers for Disease Control and Prevention
Swiss Re
Swiss Cancer Research Foundation
American Cancer Society
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献