CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma

Author:

Karkampouna Sofia1,van der Helm Danny2,Gray Peter C3,Chen Lanpeng4,Klima Irena1,Grosjean Joël1,Burgmans Mark C5,Farina-Sarasqueta Arantza6,Snaar-Jagalska Ewa B4,Stroka Deborah M7,Terracciano Luigi8,van Hoek Bart2,Schaapherder Alexander F9,Osanto Susan10,Thalmann George N111,Verspaget Hein W2,Coenraad Minneke J2,Kruithof-de Julio Marianna111ORCID

Affiliation:

1. Department of Biomedical Research, Urology Group; University of Bern; Bern Switzerland

2. Department of Gastroenterology and Hepatology; Leiden University Medical Center; Leiden The Netherlands

3. Clayton Foundation Laboratories for Peptide Biology; The Salk Institute for Biological Studies; La Jolla, California USA

4. Institute of Biology, Department of Molecular Cell Biology; Leiden University; Leiden The Netherlands

5. Department of Radiology; Leiden University Medical Centre; Leiden The Netherlands

6. Department of Pathology; Leiden University Medical Centre; Leiden The Netherlands

7. Department of Biomedical Research, Visceral Surgery and Medicine; University of Bern, Bern University Hospital; Switzerland

8. Molecular Pathology Division, Institute of Pathology; University Hospital Basel; Switzerland

9. Department of Surgery; Leiden University Medical Center; Leiden The Netherlands

10. Department of Oncology; Leiden University Medical Center; Leiden The Netherlands

11. Department of Urology; Bern University Hospital; Switzerland

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference55 articles.

1. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study;Bray;Lancet Oncol,2012

2. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis;El-Serag;Gastroenterology,2007

3. Minimally invasive local therapies for liver cancer;Li;Cancer Biol Med,2014

4. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma;European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer;J Hepatol,2012

5. Sorafenib in advanced hepatocellular carcinoma;Llovet;N Engl J Med,2008

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