Affiliation:
1. College of Marine Living Resource Sciences and Management Shanghai Ocean University Shanghai China
2. Third Institute of Oceanography, Ministry of Natural Resources Xiamen China
3. Hainan Academy of Medical Sciences Hainan Medical University Haikou China
4. School of Basic Medical Sciences Fujian Medical University Fuzhou China
Abstract
ABSTRACTFour new polyketides including one indanone (1), one isobenzofuranone (2), and two naphthoquinones (3 and 4) were isolated from the deep‐sea‐derived fungus Pseudogymnoascus hyalinus, along with 20 known compounds (5–24). The structures of new compounds were established by comprehensive analyses of their 1D and 2D NMR, HRESIMS, as well as TD‐DFT‐ECD. Compounds 5, 6, and 10 displayed potent inhibitory effects against RSL3 induced ferroptosis with EC50 values of 4.74, 1.55, and 3.72 µM, respectively.