Affiliation:
1. Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam
2. Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam
3. Drug, Comestic and Food Quality Control Center of Ha Tinh Province 46 Ha Hoang street, Thach Trung Ha Tinh 480000 Vietnam
4. Faculty of Basic Sciences Hanoi University of Mining and Geology Hanoi 10000 Vietnam
Abstract
AbstractSeven steroidal saponins including three new 16,23‐cyclocholestanes (1‐3) and one new pregane (4) were isolated from the roots of Dracaena cambodiana Pierre ex Gagnep. Their chemical structures were elucidated to be (23R,25R)‐26‐O‐β‐D‐glucopyranosyl‐16,23‐cyclocholesta‐5,17(20)‐dien‐22‐one‐3β,16α,26‐triol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐[α‐L‐rhamnopyranosyl‐(1→3)]‐β‐D‐glucopyranoside (1), (23R,25R)‐26‐O‐β‐D‐glucopyranosyl‐16,23‐cyclocholesta‐5,17,20(22)‐trien‐3β,22,26‐triol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→3)‐β‐D‐glucopyranoside (2), (23R,25R)‐16,23‐cyclocholesta‐5,16,20(22)‐trien‐3β,22,26‐triol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→3)‐β‐D‐glucopyranoside (3), 3β‐[(O‐α‐L‐rhamnopyranosyl‐(1→3)‐[α‐L‐rhamnopyranosyl‐(1→2)]‐β‐D‐gluco‐pyranosyl)oxy]‐pregna‐5,17(20)‐diene‐16‐one‐20‐carboxylic acid 4′′′′‐O‐β‐D‐glucopyranosylisopentyl ester (4), cambodianoside A (5), diosbulbiside C (6), and diosbulbiside D (7), by IR, HR‐ESI‐MS, 1D and 2D NMR spectra. Compounds 1 and 4–7 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW 264.7 cells with IC50 values ranging from 19.03±1.84 to 67.92±3.81 μM, whereas compounds 2 and 3 were inactive with IC50 values over 100 μM.
Funder
Vietnam Academy of Science and Technology
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
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