Affiliation:
1. State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guiyang 550014 China
2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550014 China
3. School of pharmaceutical Sciences Guizhou Medical University Guiyang 550014 China
4. Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Beijing 100050 China
5. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming institute of Botany, Chinese Academy of Sciences Kunming 650201 China
6. Research Unit of Chemical Biology of Natural Anti-virus Products Chinese Academy of Medical Sciences Beijing 100730 China
Abstract
AbstractTwo new ursane‐type triterpenes, eburnealactones A and B (1 and 2), one new flavonoid, eburneatin A (6), and one new phenylethanoid glycoside, chiritoside D (7), along with 9 known compounds (3–5, 8–13) were isolated from the whole plant of Primulina eburnea. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HR‐ESI‐MS). All the compounds were evaluated for their cytotoxic activities. Compound 1 showed significant cytotoxic activities against MKN‐45 cell lines and 5637 cell lines with the IC50 values of 9.57 μM and 8.30 μM, respectively. Compound 1 exhibited moderate cytotoxic activities against A549 and PATU8988T cell lines with the IC50 values of 30.70 μM and 38.22 μM, respectively. Compound 6 exhibited moderate cytotoxic activities against MKN‐45, HCT116, PATU8988T, 5637 and A‐673 cell lines with the IC50 values of 19.69 μM, 16.44 μM, 18.07 μM, 11.51 μM and 18.15 μM, respectively. Compound 5 showed moderate cytotoxic activities against A549 cell lines with the IC50 values of 24.06 μM.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering